Successful treatment of generalized pustular psoriasis with secukinumab: a report of two cases

The traditional approach is systemic treatment with acitretin, methotrexate, and cyclosporin; however, obvious side effects often occur during drug administration, limiting their clinical application. The laboratory findings on admission revealed neutrophilic leukocytosis, with a white blood cell count of 9.86 × 109/L (reference range, 3.5–9.5 × 109/L), neutrophil count of 8.09 × 109/L (reference range, 1.8–6.3 × 109/L), and C-reactive protein (CRP) level of 7.7 mg/dL (reference range, ≤0.8 mg/dL), as well as increased levels of liver enzymes and CRP. [...]he received a diagnosis of GPP. [...]activation of the tumor necrosis factor (TNF)-α/IL-17/IL-22 axis can accelerate and aggravate this reaction, and the interaction between the IL-36 axis and TNF-α/IL-17/IL-22 axis leads to GPP.