An Investigation of the Protective Effects of the Hydroalcoholic Extract of Persian Yellow Rose (Rosa foetida Herrm.) on Rats with Parkinson's Disease Induced by 6-Hydroxydopamine

Background and Aim: This study was carried out to investigate the protective impacts of Rosa foetida extract on Parkinson's disease. Materials and Methods: Seventy rats were divided into 7 groups of 10, including a sham group, the Parkinsonian group (received 6OHDA), pretreatment and post-treatment groups with Persian yellow rose extract (150 mg/kg and 300 mg/kg), and the positive control (L-DOPA). Animal behavior was evaluated using behavioral tests, including muscle stiffness test, rotarod, and elevated body swing test (EBST). The data were analyzed using SPSS statistical software. Results: The frequency of turning to the right in the EBST test, the muscle stiffness score, and the right as well as left-hand scores in the muscle stiffness test were significantly higher in the Parkinsonian group than in the sham group (P