Effect of brain exercise training on cognitive function and behavioral and psychological symptoms of patients with mild cognitive impairment

Objective To observe the effect of brain exercise training on cognitive function and behavioral and psychological symptoms of patients with mild cognitive impairment （MCI）. Methods 80 patients with MCI were randomly divided into the intervention （n = 40） and control groups （n = 40）. In the intervention group， brain exercise training was delivered for 45-60 min twice a week for 12 consecutive weeks. Mini-Mental State Examination Scale （MMSE）， Montreal Cognitive Assessment （MoCA）， Zung’s Self-rating Anxiety Scale （SAS）， Zung’s Self-rating Depression Scale （SDS）， Neuropsychiatric Inventory （NPI） and Pittsburgh Sleep Quality Index （PSQI） between two groups were evaluated at the baseline， 3 months and 6 months， respectively. Results In the control group， the total MMSE scores at 3 and 6 months were significantly declined compared with the baseline value （P < 0.001， P = 0.007）， the scores of attention and calculation domains were significantly decreased （P < 0.001， P = 0.009）， and the score of language domain was a