Matchtigs: minimum plain text representation of k-mer sets
We propose a polynomial algorithm computing a minimum plain-text representation of k-mer sets, as well as an efficient near-minimum greedy heuristic. When compressing read sets of large model organisms or bacterial pangenomes, with only a minor runtime increase, we shrink the representation by up to...
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Veröffentlicht in: | Genome Biology 2023-06, Vol.24 (1), p.136-32, Article 136 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | We propose a polynomial algorithm computing a minimum plain-text representation of k-mer sets, as well as an efficient near-minimum greedy heuristic. When compressing read sets of large model organisms or bacterial pangenomes, with only a minor runtime increase, we shrink the representation by up to 59% over unitigs and 26% over previous work. Additionally, the number of strings is decreased by up to 97% over unitigs and 90% over previous work. Finally, a small representation has advantages in downstream applications, as it speeds up SSHash-Lite queries by up to 4.26× over unitigs and 2.10× over previous work. |
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ISSN: | 1474-760X 1474-7596 1474-760X |
DOI: | 10.1186/s13059-023-02968-z |