DNA methylation microarrays identify epigenetically regulated lipid related genes in obese patients with hypercholesterolemia

Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile in peripheral leukocytes associated with elevated LDL-cholesterol level in overweight and ob...

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Veröffentlicht in:	Molecular Medicine 2020-10, Vol.26 (1), p.93-93, Article 93
Hauptverfasser:	Płatek, Teresa, Polus, Anna, Góralska, Joanna, Raźny, Urszula, Gruca, Anna, Kieć-Wilk, Beata, Zabielski, Piotr, Kapusta, Maria, Słowińska-Solnica, Krystyna, Solnica, Bogdan, Malczewska-Malec, Małgorzata, Dembińska-Kieć, Aldona
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Analysis Biomarkers Blood cholesterol Blood pressure Body mass index Body Weights and Measures Cholesterol Cholesterol tests CpG Islands Diabetes Disease Susceptibility DNA DNA Methylation DNA microarrays Epigenesis, Genetic Epigenetic inheritance Epigenetics Epigenomics - methods Fatty acids Female Fibroblast growth factors Fibroblasts Gene expression Gene Expression Regulation Gene Regulatory Networks Genes Genetic research Genomes Genomics Glucose Growth factors Humans Hypercholesterolemia Hypercholesterolemia - blood Hypercholesterolemia - etiology Hypercholesterolemia - metabolism Hypertension Insulin resistance Leptin Lipid Metabolism - genetics Lipids Lipids - blood Low density lipoprotein Low density lipoproteins Male Metabolic Networks and Pathways Metabolism Methylation Middle Aged Obesity Obesity - blood Obesity - etiology Obesity - metabolism Plasma Plasma lipids Software Type 2 diabetes Womens health
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Zusammenfassung:	Epigenetics can contribute to lipid disorders in obesity. The DNA methylation pattern can be the cause or consequence of high blood lipids. The aim of the study was to investigate the DNA methylation profile in peripheral leukocytes associated with elevated LDL-cholesterol level in overweight and obese individuals. To identify the differentially methylated genes, genome-wide DNA methylation microarray analysis was performed in leukocytes of obese individuals with high LDL-cholesterol (LDL-CH, ≥ 3.4 mmol/L) versus control obese individuals with LDL-CH,
ISSN:	1076-1551 1528-3658
DOI:	10.1186/s10020-020-00220-z