Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines

Calibrated comparison of SARS-CoV-2 neutralizing antibody levels in response to protein-, mRNA-, and vector-based COVID-19 vaccines

SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine,...

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Veröffentlicht in:npj vaccines 2022-02, Vol.7 (1), p.22-3, Article 22
Hauptverfasser: Karbiener, Michael, Farcet, Maria R., Zollner, Andreas, Masuda, Taisei, Mori, Mitsuhiro, Moschen, Alexander R., Kreil, Thomas R.
Format: Artikel
Sprache:eng
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Antibodies
Biomedical and Life Sciences
Biomedicine
Brief Communication
Coronaviruses
COVID-19
COVID-19 vaccines
Infectious Diseases
Medical Microbiology
Public Health
Severe acute respiratory syndrome coronavirus 2
Vaccine
Vaccines
Virology
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Beschreibung
Zusammenfassung:SARS-CoV-2 neutralizing antibodies have been suggested to reflect the efficacy of COVID-19 vaccines. This study reports the direct comparison of the SARS-CoV-2 neutralizing antibody response elicited by a protein- (NVX-CoV2373), an mRNA- (Comirnaty), and a vector-based (Vaxzevria) COVID-19 vaccine, calibrated against the WHO international SARS-CoV-2 antibody standard, and further supports the use of neutralizing antibody levels as a correlate of protection.
ISSN:2059-0105
2059-0105
DOI:10.1038/s41541-022-00455-3