High HbA1c levels correlate with reduced plaque regression during statin treatment in patients with stable coronary artery disease: results of the coronary atherosclerosis study measuring effects of rosuvastatin using intravascular ultrasound in Japanese subjects (COSMOS)

The incidence of cardiac events is higher in patients with diabetes than in people without diabetes. The Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS) demonstrated significant plaque regression in Japanese patients with...

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Veröffentlicht in:	Cardiovascular Diabetology 2012-07, Vol.11 (1), p.87-87
Hauptverfasser:	Daida, Hiroyuki, Takayama, Tadateru, Hiro, Takafumi, Yamagishi, Masakazu, Hirayama, Atsushi, Saito, Satoshi, Yamaguchi, Tetsu, Matsuzaki, Masunori
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Analysis Antilipemic agents Asian Continental Ancestry Group Atherosclerosis Biomarkers - blood Blood cholesterol Cardiac patients Cardiovascular agents Cardiovascular disease Care and treatment Chi-Square Distribution Coronary artery disease Coronary Artery Disease - blood Coronary Artery Disease - diagnostic imaging Coronary Artery Disease - drug therapy Coronary Artery Disease - ethnology Coronary Artery Disease - pathology Coronary heart disease Coronary vessels Coronary Vessels - diagnostic imaging Coronary Vessels - drug effects Coronary Vessels - pathology Diabetes Diabetics Drug therapy Female Fluorobenzenes - therapeutic use Glycated Hemoglobin A - metabolism Glycosylated hemoglobin HbA1c Health aspects Heart attacks Humans Hydroxymethylglutaryl-CoA Reductase Inhibitors - therapeutic use Hypercholesterolemia - blood Hypercholesterolemia - drug therapy Hypercholesterolemia - ethnology Intravascular ultrasound Japan - epidemiology Linear Models Lipids - blood Low density lipoproteins Male Measurement Medical research Middle Aged Multivariate Analysis Original Investigation Pharmaceuticals Physiological aspects Plaque, Atherosclerotic Pyrimidines - therapeutic use Risk Assessment Risk Factors Rosuvastatin Rosuvastatin Calcium Statins Sulfonamides - therapeutic use Time Factors Trans fatty acids Treatment Outcome Ultrasonography, Interventional
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Zusammenfassung:	The incidence of cardiac events is higher in patients with diabetes than in people without diabetes. The Coronary Atherosclerosis Study Measuring Effects of Rosuvastatin Using Intravascular Ultrasound in Japanese Subjects (COSMOS) demonstrated significant plaque regression in Japanese patients with chronic coronary disease after 76 weeks of rosuvastatin (2.5 mg once daily, up-titrated to a maximum of 20 mg/day to achieve LDL cholesterol
ISSN:	1475-2840 1475-2840
DOI:	10.1186/1475-2840-11-87