(1 S ,3 R )- N -{(3 S ,10 S ,12 S ,13 R ,17 R )-12-Hy-droxy-17-[( R )-5-hy-droxy-pentan-2-yl]-10,13-di-methyl-hexa-deca-hydro-1 H -cyclo-penta-[ a ]phenanthren-3-yl}adamantane-1-carboxamide 0.25-hydrate

The title compound, C H NO ·0.25H O, was synthesized from de-oxy-cholic acid followed by a protection, a Mitsonobu substitution, a Staudinger reduction, formation of an amide and final reduction in the lateral chain. The compound crystallizes in the 1 space group with four steroid mol-ecules and one water mol-ecule in the triclinic cell unit. The crystal structure features O-H⋯O hydrogen bonding. The crystal studied was refined as a non-merohedral twin.