Supplementation with NAD+ and its precursors: A rescue of female reproductive diseases

Nicotinamide adenine dinucleotide (NAD+) is an essential coenzyme involved in many pathophysiological processes. Supplementation with NAD+ and its precursors has been demonstrated as an emerging therapeutic strategy for the diseases. NAD+ also plays an important role in the reproductive system. Here, we summarize the function of NAD+ in various reproductive diseases and review the application of NAD+ and its precursors in the preservation of reproductive capacity and the prevention of embryonic malformations. It is shown that NAD+ shows good promise as a therapeutic approach for saving reproductive capacity. [Display omitted] •NAD+ precursors supplementation or depletion inhibition offers a non-invasive gynecological disease treatment.•Supplementation with NAD+ rescue ovarian aging, PCOS and assisted reproduction.•Supplementation with NAD+ rescue spontaneous abortions and congenital malformations caused by NAD+ deficiency.