Erythropoietin and Its Angiogenic Activity

Erythropoietin and Its Angiogenic Activity

Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth fac...

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Veröffentlicht in:International journal of molecular sciences 2017-07, Vol.18 (7), p.1519
Hauptverfasser: Kimáková, Patrícia, Solár, Peter, Solárová, Zuzana, Komel, Radovan, Debeljak, Nataša
Format: Artikel
Sprache:eng
Schlagworte:
angiogenesis
Animals
cancer
endothelial
erythropoietin
Erythropoietin - metabolism
erythropoietin receptor
Humans
Models, Biological
Neoplasms - metabolism
Neovascularization, Physiologic
Organ Specificity
Review
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Zusammenfassung:Erythropoietin (EPO) is the main hematopoietic hormone acting on progenitor red blood cells via stimulation of cell growth, differentiation, and anti-apoptosis. However, its receptor (EPOR) is also expressed in various non-hematopoietic tissues, including endothelium. EPO is a pleiotropic growth factor that exhibits growth stimulation and cell/tissue protection on numerous cells and tissues. In this article we review the angiogenesis potential of EPO on endothelial cells in heart, brain, and leg ischemia, as well as its role in retinopathy protection and tumor promotion. Furthermore, the effect of EPO on bone marrow and adipose tissue is also discussed.
ISSN:1422-0067
1422-0067
DOI:10.3390/ijms18071519