Association of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study

Association of low-dose glucocorticoid use and infection occurrence in systemic lupus erythematosus patients: a prospective cohort study

Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). Therefore, minimizing the risk of infection is an important clinical goal to improve the long-term prognosis of SLE patients. Treatment with [greater than or equal to]7.5 mg prednisolone (PSL) or equivalent...

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Veröffentlicht in:Arthritis research & therapy 2022-07, Vol.24 (1), p.1-179, Article 179
Hauptverfasser: Abe, Kazuya, Ishikawa, Yuichi, Kita, Yasuhiko, Yajima, Nobuyuki, Inoue, Eisuke, Sada, Ken-ei, Miyawaki, Yoshia, Yoshimi, Ryusuke, Shimojima, Yasuhiro, Ohno, Shigeru, Kajiyama, Hiroshi, Ichinose, Kunihiro, Sato, Shuzo, Fujiwara, Michio
Format: Artikel
Sprache:eng
Schlagworte:
Arthritis
Blood
Cohort analysis
Comorbidity
Corticosteroids
Development and progression
Diabetes
Dosage and administration
Drug dosages
Drug therapy
Evaluation
Glucocorticoids
Hospitalization
Hospitals
Immunosuppressive agents
Infection
Infections
Lupus
Patients
Prospective cohort study
Registration
Regression analysis
Rheumatic diseases
Rheumatology
Systemic lupus erythematosus
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Zusammenfassung:Infection is a major cause of mortality in patients with systemic lupus erythematosus (SLE). Therefore, minimizing the risk of infection is an important clinical goal to improve the long-term prognosis of SLE patients. Treatment with [greater than or equal to]7.5 mg prednisolone (PSL) or equivalent has been reported to increase the risk of infections. However, it remains unclear whether
ISSN:1478-6362
1478-6354
1478-6362
DOI:10.1186/s13075-022-02869-9