Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients

Occurrence of BRCA1 and BRCA2 mutation in pancreatic cancer patients

BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allel...

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Veröffentlicht in:Sibirskiĭ onkologicheskiĭ zhurnal 2016-02 (5), p.39-44
Hauptverfasser: A. A. Kashintsev, G. A. Yanus, N. Yu. Kokhanenko, V. M. Moiseenko, M. D. Hanevich, L. D. Roman, A. G. Ievleva, A. P. Sokolenko, E. N. Suspitsin, A. I. Budovskiy, A. V. Togo, N. M. Volkov, R. V. Fadeev, M. S. Dinikin, A. K. Ivanova, K. G. Shostko, E. N. Imyanitov
Format: Artikel
Sprache:rus
Schlagworte:
brca1
brca2
наследственный рак молочной железы и яичников
рак поджелудочной железы
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Zusammenfassung:BRCA1 and BRCA2 may contribute in pancreatic cancer (PC) risk, however the selection criteria for BRCA1 testing are poorly defined. The analysis of Russian founder mutation BRCA1 5382insC in 150 PC patients identified 2 carriers. BRCA2 full-length sequencing of 8 DNA samples revealed 1 mutated allele (BRCA2 5197_5198delTC). All 3 carriers of BRCA1/2 mutations reported personal or familial history of BRCA-related cancers. Thus, BRCA1/2 testing is particularly
ISSN:1814-4861
2312-3168