Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

Synthesis of 5-unsubstituted dihydropyrimidinone-4-carboxylates from deep eutectic mixtures

A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid- , -dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivati...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Beilstein journal of organic chemistry 2022-03, Vol.18 (1), p.331-336
Hauptverfasser: Gore, Sangram, Baskaran, Sundarababu, König, Burkhard
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Chemistry
Full Research Paper
green protocol
HIV
Human immunodeficiency virus
Ketoesters
mild conditions
no additional catalyst
Protocol
Scholarships & fellowships
solvent free
Solvents
Tartaric acid
triple role of melt
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:A facile one-pot synthesis of 5-unsubstituted dihydropyrimidinones from β,γ-unsaturated ketoesters in low melting ʟ-(+)-tartaric acid- , -dimethylurea mixtures is reported. This solvent-free method is very general and provides easy access to 5-unsubstituted dihydropyrimidinone-4-carboxylate derivatives in good yields.
ISSN:1860-5397
2195-951X
1860-5397
DOI:10.3762/bjoc.18.37