Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14

Oseltamivir-resistant influenza A(H1N1)pdm09 viruses, United States, 2013-14

We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substit...

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Veröffentlicht in:Emerging infectious diseases 2015-01, Vol.21 (1), p.136-141
Hauptverfasser: Okomo-Adhiambo, Margaret, Fry, Alicia M, Su, Su, Nguyen, Ha T, Elal, Anwar Abd, Negron, Elizabeth, Hand, Julie, Garten, Rebecca J, Barnes, John, Xiyan, Xu, Villanueva, Julie M, Gubareva, Larisa V
Format: Artikel
Sprache:eng
Schlagworte:
Adolescent
Adult
Antiviral Agents - pharmacology
Avian influenza
Dispatch
Drug Resistance, Viral
Drug therapy
Female
Forecasts and trends
Humans
influenza
Influenza A Virus, H1N1 Subtype - drug effects
Influenza A Virus, H1N1 Subtype - enzymology
Influenza A Virus, H1N1 Subtype - genetics
influenza A(H1N1)pdm09 viruses
influenza virus
Influenza, Human - drug therapy
Influenza, Human - epidemiology
Influenza, Human - virology
Male
Medical care
Middle Aged
neuraminidase
Neuraminidase - genetics
neuraminidase inhibition
Oseltamivir - pharmacology
Oseltamivir phosphate
Patient outcomes
Phylogeny
Prevalence
United States
United States - epidemiology
Viral Proteins - genetics
viruses
Young Adult
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Zusammenfassung:We report characteristics of oseltamivir-resistant influenza A(H1N1)pdm09 viruses and patients infected with these viruses in the United States. During 2013-14, fifty-nine (1.2%) of 4,968 analyzed US influenza A(H1N1)pdm09 viruses had the H275Y oseltamivir resistance-conferring neuraminidase substitution. Our results emphasize the need for local surveillance for neuraminidase inhibitor susceptibility among circulating influenza viruses.
ISSN:1080-6040
1080-6059
DOI:10.3201/eid2101.141006