Direct-on-Target Microdroplet Growth Assay Applications for Clinical Antimicrobial Susceptibility Testing

Direct-on-Target Microdroplet Growth Assay Applications for Clinical Antimicrobial Susceptibility Testing

Direct-on-target microdroplet growth assay is a new technique for analysing bacterial sensitivity and mechanisms of resistance. It is based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and allows for easy and rapid testing. Here, we describe the development and pro...

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Veröffentlicht in:Infection and drug resistance 2021-01, Vol.14, p.1423-1425
Hauptverfasser: Li, Rongrong, Tang, Hao, Xu, Huaming, Ren, Yingli, Li, Shujin, Shen, Jilu
Format: Artikel
Sprache:eng
Schlagworte:
Acids
Antibiotics
Antimicrobial agents
antimicrobial susceptibility testing
Bacteria
Cloxacillin
direct-on-target microdroplet growth assay
dot-mga
Drug resistance
E coli
Gram-negative bacteria
Imipenem
Ionization
Ions
Lasers
maldi-tof ms
Mass spectrometry
Mass spectroscopy
matrix-assisted laser desorption/ionization time-of-flight mass spectrometry
Methicillin
Microorganisms
Review
Scientific imaging
Software
Staphylococcus infections
Validity
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Zusammenfassung:Direct-on-target microdroplet growth assay is a new technique for analysing bacterial sensitivity and mechanisms of resistance. It is based on matrix-assisted laser desorption/ionization time-of-flight mass spectrometry and allows for easy and rapid testing. Here, we describe the development and procedure of the direct-on-target microdroplet growth assay and summarise the latest clinical applications.
ISSN:1178-6973
1178-6973
DOI:10.2147/IDR.S303187