Expression and clinical significance of serum complement and IL-25 in systemic lupus erythematosus

Objective To determine the differences in the expression of serum complement （C） and IL-25 in systemic lupus erythematosus （SLE） involved with single or multi-organ systems， and analyze the correlation between serum C3， C4， CH50， IL-25， C-reactive protein （CRP） and anti-dsDNA antibody. Methods A total of 151 SLE patients were included in this study. According to the organ involvement status， all patients were divided into the SLE alone （n = 58）， SLE complicated with single organ injury （n = 67， 51 cases of lupus nephritis， 13 cases of blood system injury and 3 cases of other organ injury）， and SLE complicated with multi-organ injury groups （n = 26， 25 cases of lupus nephritis complicated with other organ injury and 1 blood system complicated with brain injury）. The levels of serum C3， C4， CH50， IL-25 and CRP， and positive rate of anti-dsDNA antibody were detected among three groups. The correlation among these indexes was analyzed. Results There was no significant difference in the C4， CH50， IL-25 and CRP lev