CryoEM structure of adenovirus type 3 fibre with desmoglein 2 shows an unusual mode of receptor engagement

Attachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a cellular receptor. Here we report the cryo-electron microscopy (cryo-EM) structure of a

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Bibliographische Detailangaben
Veröffentlicht in:	Nature communications 2019-03, Vol.10 (1), p.1181-1181, Article 1181
Hauptverfasser:	Vassal-Stermann, Emilie, Effantin, Gregory, Zubieta, Chloe, Burmeister, Wim, Iseni, Frédéric, Wang, Hongjie, Lieber, André, Schoehn, Guy, Fender, Pascal
Format:	Artikel
Sprache:	eng
Schlagworte:	101/28 631/326/596/1278 631/45/535/1258/1259 82/16 82/80 82/83 Adenoviridae Infections - pathology Adenoviridae Infections - virology Adenoviruses Adenoviruses, Human - metabolism Adenoviruses, Human - pathogenicity Asparagine - genetics Biochemistry, Molecular Biology Capsid Proteins - metabolism Capsid Proteins - ultrastructure Cellular structure Cryoelectron Microscopy Desmoglein 2 - metabolism Desmoglein 2 - ultrastructure Electron microscopy HEK293 Cells Humanities and Social Sciences Humans Infections Life Sciences Models, Molecular multidisciplinary Protein Domains Proteins Receptors, Virus - metabolism Receptors, Virus - ultrastructure Recombinant Proteins - metabolism Recombinant Proteins - ultrastructure Science Science (multidisciplinary) Stoichiometry Structural Biology Trimers Virus Attachment
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Beschreibung
Zusammenfassung:	Attachment of human adenovirus (HAd) to the host cell is a critical step of infection. Initial attachment occurs via the adenoviral fibre knob protein and a cellular receptor. Here we report the cryo-electron microscopy (cryo-EM) structure of a
ISSN:	2041-1723 2041-1723
DOI:	10.1038/s41467-019-09220-y