Association of maternal serum lipids at late gestation with the risk of neonatal macrosomia in women without diabetes mellitus

Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the...

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Veröffentlicht in:Lipids in health and disease 2018-04, Vol.17 (1), p.78-78, Article 78
Hauptverfasser: Wang, Xiangxiang, Guan, Qingbo, Zhao, Jiajun, Yang, Feifei, Yuan, Zhongshang, Yin, Yongchao, Fang, Rui, Liu, Lingwei, Zuo, Changting, Gao, Ling
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Sprache:eng
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Zusammenfassung:Macrosomia is a serious public health problem worldwide due to its increasing prevalence and adverse influences on maternal and neonatal outcomes. Maternal dyslipidemia exerts potential and adverse impacts on pregnant women and newborns. However, the association between maternal serum lipids and the risk of macrosomia has not yet been clearly elucidated. We explored the association between the maternal lipids profile at late gestation and the risk of having macrosomia among women without diabetes mellitus (DM). The medical records of 5407 pregnant women giving birth to single live babies at term were retrospectively analyzed. Subjects with DM, hypertension, thyroid disorders and fetal malformation were excluded. Maternal fasting serum lipids were measured during late pregnancy. Logistic regression analysis was used to analyze the variables associated with the risk of macrosomia. Maternal serum triglyceride (TG) and high-density lipoprotein cholesterol (HDL-C) levels were related to macrosomia; each 1 mmol/L increase in TG resulted in a 27% increase in macrosomia risk, while each 1 mmol/L increase in HDL-C level resulted in a 37% decrease in macrosomia risk, even after adjusting for potential confounders. Notably, the risk of macrosomia increased progressively with increased maternal serum TG levels and decreased HDL-C levels. Compared with women with serum TG levels
ISSN:1476-511X
1476-511X
DOI:10.1186/s12944-018-0707-7