Generation of a human iPSC line from a patient with Leigh syndrome caused by a mutation in the MT-ATP6 gene

Human iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.

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Bibliographische Detailangaben
Veröffentlicht in:	Stem cell research 2016-05, Vol.16 (3), p.766-769
Hauptverfasser:	Galera-Monge, Teresa, Zurita-Díaz, Francisco, González-Páramos, Cristina, Moreno-Izquierdo, Ana, Fraga, Mario F., Fernández, Agustin F., Garesse, Rafael, Gallardo, M. Esther
Format:	Artikel
Sprache:	eng
Schlagworte:	Cell Culture Techniques - methods Cell Line Cellular Reprogramming Humans Induced Pluripotent Stem Cells - cytology Induced Pluripotent Stem Cells - metabolism Leigh Disease - genetics Mitochondrial Proton-Translocating ATPases - genetics Mutation - genetics Retrovirus
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Beschreibung
Zusammenfassung:	Human iPSC line L749.1 was generated from fibroblasts of a patient with Leigh syndrome associated with a heteroplasmic mutation in the MT-ATP6 gene. Reprogramming factors OCT4, SOX2, CMYC and KLF4 were delivered using retroviruses.
ISSN:	1873-5061 1876-7753
DOI:	10.1016/j.scr.2016.04.012