The impact of primary tumor sidedness on survival in early‐onset colorectal cancer by stage: A National Veterans Affairs retrospective analysis

The impact of primary tumor sidedness on survival in early‐onset colorectal cancer by stage: A National Veterans Affairs retrospective analysis

Background The incidence of early‐onset colorectal cancer (EOCRC) is rising. Left‐sided colorectal cancer (LCC) is associated with better survival compared to right‐sided colon cancer (RCC) in metastatic disease. NCCN guidelines recommend the addition of EGFR inhibitors to KRAS/NRAS WT metastatic CR...

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Veröffentlicht in:Cancer medicine (Malden, MA) MA), 2021-05, Vol.10 (9), p.2987-2995
Hauptverfasser: Azar, Ibrahim, Al Masalmeh, Nada, Esfandiarifard, Saghi, Virk, Gurjiwan, Kiwan, Wissam, Frank Shields, Anthony, Mehdi, Syed, Philip, Philip A.
Format: Artikel
Sprache:eng
Schlagworte:
Adult
Age
Aged
Cecum
Clinical Cancer Research
Colon cancer
Colon, Ascending - pathology
Colon, Descending - pathology
Colon, Transverse - pathology
Colonic Neoplasms - ethnology
Colonic Neoplasms - mortality
Colonic Neoplasms - pathology
Colorectal cancer
Colorectal carcinoma
Colorectal Neoplasms - ethnology
Colorectal Neoplasms - mortality
Colorectal Neoplasms - pathology
early‐onset colorectal cancer
Epidermal growth factor receptors
Ethnicity
Female
Hispanic Americans
Humans
Incidence
laterality
left‐sided colon cancer
Male
Metastases
Metastasis
Middle Aged
Mismatch repair
Mutation
Neoplasm Staging
Oncology
Original Research
Patients
Population
primary tumor sidedness
Prognosis
Rectal Neoplasms - ethnology
Rectal Neoplasms - mortality
Rectal Neoplasms - pathology
Rectum
Registries - statistics & numerical data
Retrospective Studies
right‐sided colon cancer
Spleen
Statistical analysis
Survival
Tumors
United States - epidemiology
Veterans
Young adults
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Zusammenfassung:Background The incidence of early‐onset colorectal cancer (EOCRC) is rising. Left‐sided colorectal cancer (LCC) is associated with better survival compared to right‐sided colon cancer (RCC) in metastatic disease. NCCN guidelines recommend the addition of EGFR inhibitors to KRAS/NRAS WT metastatic CRC originating from the left only. Whether laterality impacts survival in locoregional disease and EOCRC is of interest. Methods 65,940 CRC cases from the National VA Cancer Cube Registry (2001–2015) were studied. EOCRC (2096 cases) was defined as CRC diagnosed at
ISSN:2045-7634
2045-7634
DOI:10.1002/cam4.3757