Linc-ROR facilitates progression and angiogenesis of hepatocellular carcinoma by modulating DEPDC1 expression

Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its posit...

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Veröffentlicht in:	Cell death & disease 2021-11, Vol.12 (11), p.1047-13, Article 1047
Hauptverfasser:	Tian, Chuan, Abudoureyimu, Mubalake, Lin, Xinrong, Chu, Xiaoyuan, Wang, Rui
Format:	Artikel
Sprache:	eng
Schlagworte:	101/1 14/1 38/39 38/79 45/41 631/67/1504 692/699/67 Angiogenesis Animals Antibodies Base Sequence Biochemistry Biomedical and Life Sciences Carcinogenesis - genetics Carcinogenesis - pathology Carcinoma, Hepatocellular - blood supply Carcinoma, Hepatocellular - genetics Carcinoma, Hepatocellular - pathology Cell Biology Cell Culture Cell Line, Tumor Cell Proliferation - genetics Disease Progression Epithelial-Mesenchymal Transition - genetics Female Gene Expression Regulation, Neoplastic GTPase-Activating Proteins - genetics GTPase-Activating Proteins - metabolism Hepatocellular carcinoma Heterogeneous-Nuclear Ribonucleoprotein K - genetics Heterogeneous-Nuclear Ribonucleoprotein K - metabolism Human Umbilical Vein Endothelial Cells - metabolism Humans Immunology Life Sciences Liver cancer Liver Neoplasms - blood supply Liver Neoplasms - genetics Liver Neoplasms - pathology Male Mice Mice, Inbred BALB C Mice, Nude MicroRNAs - genetics MicroRNAs - metabolism Middle Aged mRNA stability Neoplasm Invasiveness Neoplasm Proteins - genetics Neoplasm Proteins - metabolism Neovascularization, Pathologic - genetics Protein Binding RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism RNA, Messenger - genetics RNA, Messenger - metabolism Up-Regulation - genetics
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Zusammenfassung:	Linc-ROR have been well-demonstrated to play important roles in cancer progression and angiogenesis. However, the underlying oncogenic mechanism of Linc-ROR in hepatocellular carcinoma is poorly understood. In this study, we demonstrate that Linc-ROR plays an oncogenic role in part through its positive regulation of DEPDC1 expression. Mechanistically, Linc-ROR acts as competing endogenous RNA to stabilize DEPDC1 mRNA and regulates DEPDC1 mRNA stability by binding HNRNPK. Thus, these findings suggest that function of Linc-ROR-mediated DEPDC1 could predispose hepatocellular carcinoma patients to progression and angiogenesis, and may serve as a potential target for anticancer therapies.
ISSN:	2041-4889 2041-4889
DOI:	10.1038/s41419-021-04303-5