Mahimbrine A, a Novel Isoquinoline Alkaloid Bearing a Benzotropolone Moiety from Mahonia imbricata

A novel isoquinoline alkaloid, mahimbrine A, possessing a rare benzotropolone framing scaffold, was isolated from the endemic plant of . Its structure was established on the basis of extensive spectroscopic analysis. A plausible biosynthetic route of mahimbrine A was proposed. Mahimbrine A showed no...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2018-06, Vol.23 (7), p.1539
Hauptverfasser:	Zhang, Mao-Sheng, Deng, Yan, Fu, Shao-Bin, Guo, Da-Le, Xiao, Shi-Ji
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - chemical synthesis Alkaloids - chemistry Alkaloids - pharmacology Anti-Infective Agents - pharmacology Antimicrobial activity Berberidaceae Biflavonoids - chemistry Carbon-13 Magnetic Resonance Spectroscopy Catechin - analogs & derivatives Catechin - chemistry Chinese medicine Endemic plants Gram-negative bacteria isoquinoline alkaloid Isoquinolines - chemical synthesis Isoquinolines - chemistry Isoquinolines - pharmacology mahimbrine A Mahonia Mahonia - chemistry Mahonia imbricata Metabolites Microbial Sensitivity Tests Pharmacy Phytochemicals Proton Magnetic Resonance Spectroscopy Spectrum analysis Tuberculosis
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Beschreibung
Zusammenfassung:	A novel isoquinoline alkaloid, mahimbrine A, possessing a rare benzotropolone framing scaffold, was isolated from the endemic plant of . Its structure was established on the basis of extensive spectroscopic analysis. A plausible biosynthetic route of mahimbrine A was proposed. Mahimbrine A showed no antimicrobial activity at the concentration of 1 mg/mL.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules23071539