Generation of an integration-free induced pluripotent stem cell (iPSC) line (ZZUNEUi004-A) from a Wilson's disease patient harboring a homozygous Pro992Leu mutation in ATP7B gene

Human IPSC Line, ZZUNEUi004-A, was generated from a 34-year-old male patient with Wilson's Disease carrying a homozygous Pro992Leu mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.

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Bibliographische Detailangaben
Veröffentlicht in:	Stem cell research 2020-04, Vol.44, p.101741-101741, Article 101741
Hauptverfasser:	Zhang, Jiwei, Wei, Liting, Chen, Dingbang, Feng, Li, Wu, Chao, Wang, Rui, Li, Xunhua, Liu, Hongbo
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Cell Line Copper-Transporting ATPases - genetics Hepatolenticular Degeneration - genetics Homozygote Humans Induced Pluripotent Stem Cells Male Mutation
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Beschreibung
Zusammenfassung:	Human IPSC Line, ZZUNEUi004-A, was generated from a 34-year-old male patient with Wilson's Disease carrying a homozygous Pro992Leu mutation in ATP7B gene, using non-integrative reprogramming method. This cell line shows pluripotency both in vitro and vivo, and has a normal karyotype.
ISSN:	1873-5061 1876-7753
DOI:	10.1016/j.scr.2020.101741