The Integrative Studies on the Functional A-to-I RNA Editing Events in Human Cancers

Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers. However, the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient. To fill this gap,...

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Veröffentlicht in:Genomics, proteomics & bioinformatics proteomics & bioinformatics, 2023-06, Vol.21 (3), p.619-631
Hauptverfasser: Wu, Sijia, Fan, Zhiwei, Kim, Pora, Huang, Liyu, Zhou, Xiaobo
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Sprache:eng
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Zusammenfassung:Adenosine-to-inosine (A-to-I) RNA editing, constituting nearly 90% of all RNA editing events in humans, has been reported to contribute to the tumorigenesis in diverse cancers. However, the comprehensive map for functional A-to-I RNA editing events in cancers is still insufficient. To fill this gap, we systematically and intensively analyzed multiple tumorigenic mechanisms of A-to-I RNA editing events in samples across 33 cancer types from The Cancer Genome Atlas. For individual candidate among ∼1.5 M quantified RNA editing events, we performed diverse types of down-stream functional annotations. Finally, we identified 24,236 potentially functional A-to-I RNA editing events, including the cases in APOL1, IGFBP3, GRIA2, BLCAP, and miR-589-3p. These events might play crucial roles in the scenarios of tumorigenesis, due to their tumor-related editing frequencies or probable effects on altered expression profiles, protein functions, splicing patterns, and microRNA regulations of tumor genes. Our functional A-to-I RNA editing events (https://ccsm.uth.edu/CAeditome/) will help better understanding of cancer pathology from A-to-I RNA editing aspect.
ISSN:1672-0229
2210-3244
DOI:10.1016/j.gpb.2022.12.010