Feasibility study of non-contact measurement in mechanical verification method for dissolution instrument

Dissolution instrument is an effective alternative method to study and evaluate the bioavailability of drugs in vitro, and an important means to ensure and evaluate whether the production technology and quality of solid oral preparations are reasonable and stable. It is found that the mechanical pro...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Zhou, Wei, Yao, Mi
Format: Tagungsbericht
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Dissolution instrument is an effective alternative method to study and evaluate the bioavailability of drugs in vitro, and an important means to ensure and evaluate whether the production technology and quality of solid oral preparations are reasonable and stable. It is found that the mechanical properties of the instrument will affect the determination of the drug, which will lead to the deviation of the determination results. Some methods of mechanical verification of dissolution instrument are analyzed and the application of non-contact measurement method is explored in mechanical verification. Experimental results show that the proposed non-contact measurement method has good measurement accuracy and repeatability.
ISSN:2267-1242
2555-0403
2267-1242
DOI:10.1051/e3sconf/202125702058