Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting

Evaluation of Hydrogels Based on Oxidized Hyaluronic Acid for Bioprinting

In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid di...

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Veröffentlicht in:Gels 2018-10, Vol.4 (4), p.82
Hauptverfasser: Weis, Matthias, Shan, Junwen, Kuhlmann, Matthias, Jungst, Tomasz, Tessmar, Jörg, Groll, Jürgen
Format: Artikel
Sprache:eng
Schlagworte:
Aldehydes
Amino acids
Aqueous solutions
Bioengineering
biofabrication
bioprinting
Communication
Crosslinking
Hyaluronic acid
Hydrogels
Imines
Molecular weight
Polymers
Reagents
Rheological properties
Three dimensional printing
Viscosity
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Beschreibung
Zusammenfassung:In this study, we evaluate hydrogels based on oxidized hyaluronic acid, cross-linked with adipic acid dihydrazide, for their suitability as bioinks for 3D bioprinting. Aldehyde containing hyaluronic acid (AHA) is synthesized and cross-linked via Schiff Base chemistry with bifunctional adipic acid dihydrazide (ADH) to form a mechanically stable hydrogel with good printability. Mechanical and rheological properties of the printed and casted hydrogels are tunable depending on the concentrations of AHA and ADH cross-linkers.
ISSN:2310-2861
2310-2861
DOI:10.3390/gels4040082