Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

Association of blood pressure and renal outcome in patients with chronic kidney disease; a post hoc analysis of FROM-J study

It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among differe...

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Veröffentlicht in:Scientific reports 2021-07, Vol.11 (1), p.14990-14990, Article 14990
Hauptverfasser: Tsuchida-Nishiwaki, Mariko, Uchida, Haruhito A., Takeuchi, Hidemi, Nishiwaki, Noriyuki, Maeshima, Yohei, Saito, Chie, Sugiyama, Hitoshi, Wada, Jun, Narita, Ichiei, Watanabe, Tsuyoshi, Matsuo, Seiichi, Makino, Hirofumi, Hishida, Akira, Yamagata, Kunihiro
Format: Artikel
Sprache:eng
Schlagworte:
692/4022
692/699/75/243
Blood pressure
Glomerular filtration rate
Humanities and Social Sciences
Hypertension
Kidney diseases
Kidneys
multidisciplinary
Patients
Proteinuria
Science
Science (multidisciplinary)
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Zusammenfassung:It is well-known that hypertension exacerbates chronic kidney disease (CKD) progression, however, the optimal target blood pressure (BP) level in patients with CKD remains unclear. This study aimed to assess the optimal BP level for preventing CKD progression. The risk of renal outcome among different BP categories at baseline as well as 1 year after, were evaluated using individual CKD patient data aged between 40 and 74 years from FROM-J [Frontier of Renal Outcome Modifications in Japan] study. The renal outcome was defined as ≥ 40% reduction in estimated glomerular filtration rate to 
ISSN:2045-2322
2045-2322
DOI:10.1038/s41598-021-94467-z