Early-Onset Neonatal Sepsis in Turkey: A Single-Center 7-Year Experience in Etiology and Antibiotic Susceptibility
The pathogen distribution and antibiotic susceptibility of the pathogens in early-onset sepsis (EOS) differ between countries. The epidemiological data from a limited number of studies about EOS in Turkey are insufficient. In this study, we aimed to evaluate the culture-proven EOS cases, causative m...
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Veröffentlicht in: | Children (Basel) 2022-10, Vol.9 (11), p.1642 |
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Zusammenfassung: | The pathogen distribution and antibiotic susceptibility of the pathogens in early-onset sepsis (EOS) differ between countries. The epidemiological data from a limited number of studies about EOS in Turkey are insufficient. In this study, we aimed to evaluate the culture-proven EOS cases, causative microorganisms, antibiotic susceptibility patterns, and risk factors for mortality in EOS.
This is a retrospective, single-center study over a 7-year period, from 2013 to 2020, at Zeynep Kamil Maternity and Children's Hospital, İstanbul, Turkey.
During the study period, 8229 newborns were admitted to our neonatal intensive care unit. Culture-proven EOS was detected in 101 patients (0.12%). Out of these, 56 (55.4%) were Gram-positive, and 45 (44.5%) were Gram-negative sepsis. The most common isolated organism was
(28.7%,
= 29), followed by GBS (16.8%,
= 17) and
(15.8%,
= 16). An ampicillin and gentamicin combination had antimicrobial coverage in 92.6% of cases. Seventeen patients (16.8%) died because of EOS. Severe neutropenia was found to be an independent risk factor for mortality in EOS (
= 0.001, OR = 14.4, CI 95%: 2.8-74).
Although the majority of causative agents were Gram-positive (55.4%), the most common isolated organism was
An empirical antibiotic regimen of ampicillin and gentamicin continues to have an adequate coverage for EOS in our population. |
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ISSN: | 2227-9067 2227-9067 |
DOI: | 10.3390/children9111642 |