Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa

Isolaurenidificin and Bromlaurenidificin, Two New C15-Acetogenins from the Red Alga Laurencia obtusa

Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spect...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2017-05, Vol.22 (5), p.807
Hauptverfasser: Bawakid, Nahed, Alarif, Walied, Alburae, Najla, Alorfi, Hajer, Al-Footy, Khalid, Al-Lihaibi, Sultan, Ghandourah, Mohamed
Format: Artikel
Sprache:eng
Schlagworte:
Algae
anti-inflammatory
Apoptosis
Artemia
Breast cancer
Chromatography
Cytotoxicity
fatty acids
Fractionation
halogenations
Leukocytes (neutrophilic)
Liver cancer
marine algae
Metabolites
Peripheral blood
Prostate cancer
Spectra
spectroscopy
Toxicity
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Zusammenfassung:Chromatographic fractionation of the CH2Cl2/MeOH extract of the Red Sea red alga Laurencia obtusa gave two new hexahydrofuro[3,2-b]furan-based C15-acetogenins, namely, isolaurenidificin (1) and bromlaurenidificin (2). The chemical structures were elucidated based on extensive analyses of their spectral data. Compounds 1 and 2 showed no toxicity (LC50 > 12 mM) using Artemia salina as test organism. Both compounds showed weak cytotoxicity against A549, HepG-2, HCT116, MCF-7, and PC-3 cells, however, they exhibited a relatively potent cytotoxic activity against peripheral blood neutrophils. This can be attributed partly to induction of apoptosis.
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules22050807