Studies on Synthesis of Some New Chalcone and Pyrimidines and their Antibacterial Activity

Pyrimidine‐2‐one derivatives, 2‐[2‐{1ʹ‐(p‐nitrophenyl)‐6ʹ‐(substituted‐phenyl)‐pyrimidine‐2ʹ‐one‐4ʹ‐yl}‐hydrazinomethyl]‐3‐(p‐methoxy phenyl)‐quina‐zoline‐4(3H)‐one [ 4a-j ] have been synthesised by the condensation of p ‐nitro phenylurea and various chalcones, 2‐(substituted phenylchalconylhydrazinomethyl)‐3‐(p‐methoxyphenyl)‐quinazoline‐4(3H)‐one [ 3a-j ] in the presence of catalytic amount of conc. HCl. And this series of chalcones have been synthesised by the reaction of 2‐acetylhydrazinomethyl‐3‐(substitutedphenyl)‐quinazoline‐4(3H)‐one [2] with different substituted aldehydes in presence of a 2% NaOH solution. These products have been characterized by means of elemental analysis, IR and NMR spectrul studies and tested for antibacterial activities against Staphylococcus aureus , Bacillus subtillis , Escherichia coli and Salmonella typhi .