Comparison of Three Different Diet-Induced Non Alcoholic Fatty Liver Disease Protocols in Rats: A Pilot Study

[...]NASH development requires a double hit, the "1st hit' causes lipid accumulation in hepatocytes, and the "2nd hit' causes inflammation and fibrosis.9 Fat accumulation in the liver is associated with metabolic disorders related to central obesity and insulin resistance.10 Nowadays, we still do not have an effective and consensus therapeutic option for NAFLD except lifestyle modification including weight reduction diets and exercise.6 Due to limitations of human studies on NAFLD/NASH (such as ethical limitations in administering drugs, use of liver biopsy and the long period of development and progression of disease), animal models can give definitive information, not only in clarifying the pathogenesis of NAFLD but also in examining therapeutic effects of numerous agents.