EFFECTIVENESS OF FIXED COMBINATION OF RAMIPIL/AMLODIPINE IN THERAPY OF ARTERIAL HYPERTENSION, CHRONIC KIDNEY DISEASE AND DIABETES MELLITUS

The review is devoted to the problem of kidney damage as the arterial hypertension target organ. The data on prevalence of chronic renal disease at arterial hypertension, diagnostics and on approaches to therapy are provided. From positions of modern recommendations on therapy of arterial hypertension issues of target levels of arterial pressure in patients with combined kidney damage and/or diabetes mellitus, selection of antihypertensive drugs in these clinical situations, first of all, rational combinations of antihypertensive drugs are provided. Results of studies evidencing advantages of a combination of the angiontensin-converting ferment with calcium antagonist for therapy of drugs with arterial hypertension, diabetes mellitus and kidney damage are discussed. Advantages of ramipril for therapy of this category of patients are highlighted. The article provides data on the large RAMONA study that identified its high effectiveness and safety as well as positive metabolic effects of the fixed combination of ramipril with amlodipine.