Impact of Tobacco Use on Oral Cancer Incidence among Women in Urban Slums: A Case-Control Study

ABSTRACT Background: Oral cancer represents a significant global health burden, disproportionately affecting vulnerable populations in developing countries like India. Urban slums, characterized by socioeconomic challenges and limited access to healthcare, are particularly susceptible. This study aimed to examine the association between tobacco use, a well-established risk factor, and the incidence of oral cancer among women residing in these underserved communities. Methods: A case-control study was conducted, involving 300 women from urban slums: 150 cases diagnosed with oral cancer within the past year and 150 controls without a history of the disease. Data were collected through structured interviews, encompassing tobacco use habits (type, frequency, and duration), sociodemographic factors, and oral hygiene practices. Statistical analyses, including Chi-square tests and logistic regression, were employed to assess the association between tobacco use and oral cancer risk. Results: The study revealed a strong association between tobacco use and oral cancer among women in urban slums. The prevalence of tobacco use, particularly smokeless tobacco, was significantly higher in cases compared to controls. Smokeless tobacco use and smoking emerged as independent risk factors for oral cancer. Lower educational attainment was also identified as an independent risk factor, underscoring the influence of socioeconomic disadvantages on disease susceptibility. Conclusion: This study provides compelling evidence linking tobacco use to a heightened risk of oral cancer among women in urban slums. The findings underscore the urgent need for targeted interventions, including health education, access to cessation programs, and addressing socioeconomic disparities, to mitigate the burden of oral cancer in this vulnerable population. The study highlights the importance of culturally sensitive and effective preventive measures to combat oral cancer in underserved communities. Keywords: Oral cancer, tobacco use, urban slums, women