A Novel Utilization of Water Extract of Suaeda Salsa in the Pd/C Catalyzed Suzuki–Miyaura Coupling Reaction

Using biomass-derived solvents in various organic reactions is challenging for the fine chemicals industry. We herein report a Pd/C catalyzed Suzuki–Miyaura reaction in water extract of suaeda salsa (WES) without using external phosphine ligand, base, and organic solvent. The cross-coupling reaction...

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Veröffentlicht in:	Molecules (Basel, Switzerland) Switzerland), 2022-10, Vol.27 (19), p.6623
Hauptverfasser:	Ren, Changyue, Zhang, Hang, Chen, Zhengjun, Gao, Jie, Yang, Mingyan, Yuan, Zeli, Li, Xinmin
Format:	Artikel
Sprache:	eng
Schlagworte:	Acids Aqueous solutions Chemical industry Chemical reactions Chromatography Column chromatography Cross coupling Fine chemicals Functional groups Herbicides ligand-free Ligands Pd/C Pesticides industry Solvents suaeda salsa Suzuki–Miyaura reactions Valsartan water Water use
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Beschreibung
Zusammenfassung:	Using biomass-derived solvents in various organic reactions is challenging for the fine chemicals industry. We herein report a Pd/C catalyzed Suzuki–Miyaura reaction in water extract of suaeda salsa (WES) without using external phosphine ligand, base, and organic solvent. The cross-coupling reactions were carried out in a basic WES medium with a broad substrate scope and wide functional group tolerance. Furthermore, the high purity of solid biaryl products can be obtained by column chromatography or filtration.
ISSN:	1420-3049 1420-3049
DOI:	10.3390/molecules27196623