Earlier Age at Menopause, Plasma Metabolome, and Risk of Premature Mortality

Menopause and related metabolites are associated with mortality. However, the relationship between earlier menopause, premature mortality, and the role of metabolomic signatures remains underexplored. This study investigated the association between earlier menopause and premature mortality, and the...

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Veröffentlicht in:	Metabolites 2024-10, Vol.14 (11), p.571
Hauptverfasser:	Yang, Zeping, Huang, Ninghao, Zhuang, Zhenhuang, Jin, Ming, Zhang, Ziyi, Song, Yimin, Cui, Haoliang, Zhang, Shan, Huang, Tao, Liu, Xiaojing, Li, Nan
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Alcohol use Amino acids Biobanks Biomarkers Body mass index Cardiovascular disease China Cholesterol earlier age at menopause Endocrine therapy Exercise Health aspects Health services Kidney diseases Liver diseases Mediation mediation analysis Menopause Metabolites Metabolomics Mortality NMR Nuclear magnetic resonance Plasma plasma metabolome Post-menopause Postmenopausal women Premature mortality Spectrum analysis Survival analysis Triglycerides Type 2 diabetes United Kingdom Zhang Ziyi
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Zusammenfassung:	Menopause and related metabolites are associated with mortality. However, the relationship between earlier menopause, premature mortality, and the role of metabolomic signatures remains underexplored. This study investigated the association between earlier menopause and premature mortality, and the mediating effect of metabolomic signatures. This prospective cohort study used data from the UK Biobank, including 33,687 post-menopausal women aged 40-69 years. Age at menopause was obtained from a baseline self-reported questionnaire and analyzed both as a continuous variable and in categories (
ISSN:	2218-1989 2218-1989
DOI:	10.3390/metabo14110571