Neonatal Natural Killer Cell Function: Relevance to Antiviral Immune Defense

Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phe...

Ausführliche Beschreibung

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Clinical & developmental immunology 2013-01, Vol.2013 (2013), p.1-6
Hauptverfasser:	Lee, Yen-Chang, Lin, Syh-Jae
Format:	Artikel
Sprache:	eng
Schlagworte:	Adaptive Immunity Comparative analysis Cytokines - biosynthesis Cytotoxicity, Immunologic Health aspects Humans Immune system Immunity, Innate Immunology Infant, Newborn Infants (Newborn) Infections Interleukin-15 - metabolism Killer cells Killer Cells, Natural - immunology Killer Cells, Natural - metabolism Phenotype Physiological aspects Review Viral infections Virus Diseases - immunology
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	Neonates are particularly susceptible to various pathogens compared to adults, which is attributed in part to their immature innate and adaptive immunity. Natural killer cells provide first-line innate immune reactions against virus-infected cells without prior sensitization. This review updates phenotypic and functional deficiencies of neonatal cells compared to their adult counterparts and their clinical implications.
ISSN:	2314-8861 1740-2522 2314-7156 1740-2530
DOI:	10.1155/2013/427696