Evaluating the Impact of CYP3A5 Genotype on Post-Transplant Healthcare Resource Utilization in Pediatric Renal and Heart Transplant Recipients Receiving Tacrolimus

Purpose: CYP3A5 genotype is a significant contributor to inter-individual tacrolimus exposure and may impact the time required to achieve therapeutic concentrations and number of tacrolimus dose adjustments in transplant patients. Increased modifications to tacrolimus therapy may indicate a higher b...

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Veröffentlicht in:	Pharmacogenomics and personalized medicine 2021-01, Vol.14, p.319-326
Hauptverfasser:	Pasternak, Amy L., Marshall, Vincent D., Gersch, Christina L., Rae, James M., Englesbe, Michael, Park, Jeong M.
Format:	Artikel
Sprache:	eng
Schlagworte:	Age Analysis Biopsy Blood & organ donations Care and treatment cost of care Demographics Deoxyribonucleic acid DNA Dosage Drug dosages Electronic medical records Genetic aspects Genetic testing Genotype & phenotype Genotypes Genotyping Graft rejection Health aspects Heart Heart transplantation Heart transplants Immunosuppression Immunotherapy Induction therapy Kidney transplantation Kidney transplants Kidneys Laboratories Life Sciences & Biomedicine Medical care Medical records Organ transplant recipients Original Research Patients pediatric transplant Pediatrics Pharmacogenetics Pharmacology & Pharmacy Phenotypes Resource utilization Science & Technology Tacrolimus Transplantation Utilization Variables
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Zusammenfassung:	Purpose: CYP3A5 genotype is a significant contributor to inter-individual tacrolimus exposure and may impact the time required to achieve therapeutic concentrations and number of tacrolimus dose adjustments in transplant patients. Increased modifications to tacrolimus therapy may indicate a higher burden on healthcare resources. The purpose of this study was to evaluate whether CYP3A5 genotype was predictive of healthcare resource utilization in pediatric renal and heart transplant recipients. Patients and Methods: Patients
ISSN:	1178-7066 1178-7066
DOI:	10.2147/PGPM.S285444