INFLAMMATORY MARKERS AND OXIDATIVE STRESS IN ASSOCIATION WITH PERIODONTAL DISEASE AND SYSTEMIC CONDITIONS. Review

Periodontal disease appears from the action of bacteria and their products. Manifestations of periodontal disease are inflammatory and they comes from the interaction between the bacterial plaque and the host’s immune and inflammatory response. Pro-inflammatory mediators such as cytokines, chemokines and metalloproteinases are known to increase dramatically in periodontal tissues and gingival crevicular fluid in periodontitis. On the other way, inflammation in periodontitis determines and maintains a systemic inflammatory condition, favoring the evolution of diseases such as diabetes, cardiovascular disease, obesity, rheumatoid arthritis, and these diseases, in turn, through systemic inflammation, cause local inflammatory changes. Oxidative stress has been implicated in many disease and is one of the main factors studied to explain the pathophysiological mechanisms of inflammatory conditions, such as obesity and periodontitis.