CIC-rearranged round cell (Ewing-like) sarcoma of the uterus: Review of the literature

•CIC-rearranged round-cell sarcoma is a rare entity often mistaken for Ewing sarcoma.•Paper reports: 29-year old women diagnosed with CIC-rearranged sarcoma of the uterus.•This is the first case of its kind reported in the literature.•Clinical/therapeutic similarities/differences between CIC and Ewing sarcomas.•Emphasis on further studies necessary to investigate CIC-rearranged sarcoma. CIC-rearranged round cell sarcoma (CRS) is a rare entity that presents in various anatomical locations and involves deep soft-tissue structures and skin. Although commonly confused with and clinically similar to Ewing sarcoma (ES), investigators have recently shown that this unique condition maintains morphologic and pathologic features that are distinct from ES. In this report, we present and discuss a case of CRS of the uterus, the first of its kind to be reported in the English-language literature. We urge the scientific community to continue its investigations in elucidating the features of this entity, as young women who suffer from this condition have dismal prognoses and currently do not have access to therapeutic options for cure.