Plasma EBV DNA: A Promising Diagnostic Marker for Endemic Burkitt Lymphoma

Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in regions of equatorial Africa where malaria is holoendemic. The tumor is consistently associated with Epstein-Barr virus (EBV). Screening for EBV DNA in plasma in a high-risk population in Hong Kong has been shown to be useful in f...

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Veröffentlicht in:	Frontiers in oncology 2021-12, Vol.11, p.804083-804083
Hauptverfasser:	Xian, Rena R, Kinyera, Tobias, Otim, Isaac, Sampson, Joshua N, Nabalende, Hadijah, Legason, Ismail D, Stone, Jennifer, Ogwang, Martin D, Reynolds, Steven J, Kerchan, Patrick, Bhatia, Kishor, Goedert, James J, Mbulaiteye, Sam M, Ambinder, Richard F
Format:	Artikel
Sprache:	eng
Schlagworte:	Burkitt lymphoma cell-free DNA Epstein-Barr virus malaria Oncology plasma DNA
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Zusammenfassung:	Endemic Burkitt lymphoma (eBL) is the most common childhood cancer in regions of equatorial Africa where malaria is holoendemic. The tumor is consistently associated with Epstein-Barr virus (EBV). Screening for EBV DNA in plasma in a high-risk population in Hong Kong has been shown to be useful in facilitating the early diagnosis of nasopharyngeal carcinoma, another EBV-associated tumor. Here, we investigate plasma EBV as a diagnostic marker for eBL in children in Uganda. We studied plasma specimens from 25 children with eBL and 25 controls matched for age (
ISSN:	2234-943X 2234-943X
DOI:	10.3389/fonc.2021.804083