ZnO-NPs alleviate aflatoxin B1-induced hepatoxicity in ducklings by promoting hepatic metallothionein expression

ZnO-NPs alleviate aflatoxin B1-induced hepatoxicity in ducklings by promoting hepatic metallothionein expression

Aflatoxin B1 (AFB1) is a mycotoxin widely present in animal feed and human food, posing a serious threat to animal and human health. This study was aim to illustrate the mechanism of the protective role of MT against AFB1-induced hepatotoxicity, as well as to explore the feasibility of enhancing the...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Ecotoxicology and environmental safety 2023-05, Vol.256, p.114826-114826, Article 114826
Hauptverfasser: Zhang, Beiyu, Li, Meiling, Zhou, Guangteng, Gu, Xin, Xie, Longqiang, Zhao, Man, Xu, Qingbiao, Tan, Gaoming, Zhang, Niya
Format: Artikel
Sprache:eng
Schlagworte:
Aflatoxin B1
Ducklings
Liver
Metal-regulatory transcription factor-1
Metallothionein
ZnO-NPs
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Aflatoxin B1 (AFB1) is a mycotoxin widely present in animal feed and human food, posing a serious threat to animal and human health. This study was aim to illustrate the mechanism of the protective role of MT against AFB1-induced hepatotoxicity, as well as to explore the feasibility of enhancing the tolerance of poultry to AFB1 by upregulating the expression of hepatic MT. After being exposed to AFB1 (50 ng/kg) primary duckling hepatocytes, the cell viability, the antioxidant index (SOD and GPx) and the mRNA levels of MT downstream genes (PTGR, p53, TrxR, AR and Bcl-2) significantly (p 
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2023.114826