Mechanisms That Regulate Peripheral Immune Responses to Control Organ-Specific Autoimmunity

The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self-proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 a...

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Veröffentlicht in:Clinical & developmental immunology 2011-01, Vol.2011 (2011), p.1-9
1. Verfasser: Hoyne, Gerard F.
Format: Artikel
Sprache:eng
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Zusammenfassung:The immune system must balance the need to maintain a diverse repertoire of lymphocytes to be able to fight infection with the need to maintain tolerance to self-proteins. The immune system places strict regulation over the ability of T cells to produce the major T cell growth factor interleukin 2 as this cytokine can influence a variety of immune outcomes. T cells require the delivery of two signals, one through the antigen receptor and a second through the costimulatory receptor CD28. The immune system uses a variety of E3 ubiquitin ligases to target signaling proteins that function downstream of the TCR and CD28 receptors. Mutations in these E3 ligases can lead to a breakdown in immune tolerance and development of autoimmunity. This paper will examine the role of a range of E3 ubiquitin ligases and signaling pathways that influence the development of T-cell effector responses and the development of organ-specific autoimmune diseases such as type 1 diabetes.
ISSN:1740-2522
2314-8861
1740-2530
2314-7156
DOI:10.1155/2011/294968