Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism

Plasma fibroblast growth factor-21 levels in patients with inborn errors of metabolism

Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM....

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Veröffentlicht in:Molecular genetics and metabolism reports 2017-12, Vol.13 (C), p.52-54
Hauptverfasser: Kirmse, Brian, Cabrerra-Luque, Juan, Ayyub, Omar, Cusmano, Kristina, Chapman, Kimberly, Summar, Marshall
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Sprache:eng
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Zusammenfassung:Fibroblast growth factor-21 (FGF21) levels are elevated in patients with primary mitochondrial disorders but have not been studied in patients with inborn errors of metabolism (IEM) known to have secondary mitochondrial dysfunction. We measured plasma FGF21 by ELISA in patients with and without IEM. FGF21 levels were higher in patients with IEM compared to without IEM (370pg/dL vs. 0–65pg/dL). Further study of FGF21 as a biomarker in IEM is warranted.
ISSN:2214-4269
2214-4269
DOI:10.1016/j.ymgmr.2017.04.001