Lack of MERS coronavirus neutralizing antibodies in humans, eastern province, Saudi Arabia

We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS...

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Veröffentlicht in:	Emerging infectious diseases 2013-12, Vol.19 (12), p.2034-2036
Hauptverfasser:	Gierer, Stefanie, Hofmann-Winkler, Heike, Albuali, Waleed H, Bertram, Stephanie, Al-Rubaish, Abdullah M, Yousef, Abdullah A, Al-Nafaie, Awatif N, Al-Ali, Amein K, Obeid, Obeid E, Alkharsah, Khaled R, Pöhlmann, Stefan
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antibodies Antibodies, Neutralizing - blood Antibodies, Neutralizing - immunology Antibodies, Viral - blood Antibodies, Viral - immunology Coronavirus - immunology Coronavirus Infections - epidemiology Coronavirus Infections - immunology Coronavirus Infections - transmission Dispatch Female Health aspects Humans Infection Male MERS coronavirus MERS-CoV Middle Aged neutralizing antibodies pseudotyping Saudi Arabia Saudi Arabia - epidemiology Seroepidemiologic Studies spike Viral antibodies Young Adult
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Beschreibung
Zusammenfassung:	We used a lentiviral vector bearing the viral spike protein to detect neutralizing antibodies against Middle East respiratory syndrome coronavirus (MERS-CoV) in persons from the Eastern Province of Saudi Arabia. None of the 268 samples tested displayed neutralizing activity, which suggests that MERS-CoV infections in humans are infrequent in this province.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1912.130701