Research progress on miRNA in airway remodeling

Airway remodeling refers to the structural and functional changes of airway tissues caused by repeated chronic inflammatory stimulation injury and incomplete repair. It is commonly seen in chronic airway inflammatory diseases, such as asthma and COPD, which is an important cause of irreversible airway stenosis and restricted airflow. MicroRNA （miRNA） molecules are involved in almost all pathophysiological processes in the human body, and they are excellent functional gene regulators. Recent studies have found that miRNA affects airway smooth muscle cell proliferation and migration, epithelial cell proliferation and adhesion, fibroblast proliferation, airway angiogenesis, goblet cell secretion and airway inflammation through different pathways and targets, thus further affecting airway remodeling. In this article, the research progresses on miRNA in airway remodeling were reviewed.