In vitro and in silico study on the seeds of Veitchia merrillii on trematode worms

The potential of plants as anthelmintics is very large, but there is still very little research conducted in the search for effective, safe, easily obtained, and affordable anthelmintic candidates. Palem putri ( ) is an ornamental plant that is interesting to study because it is included in the areca nut group which is reported to have strong abilities as anthelmintics. The study aims to evaluate the anthelmintic efficacy of against trematode worms such as spp. and . This research employs both and computational techniques. An anthelmintic test was carried out on spp. worms at concentrations of 10%, 25%, and 40% (gr/v), assessing mortality index as the observable outcome, followed by a histopathological investigation of the deceased worms for tissue and cellular damage evaluation. Seventeen compounds from seeds were studied for their anthelmintic activity against worms using the quantitative structure-activity relationship technique, molecular docking, and Lipinski's rule analysis for orally administered medication. About 25% and 40% extracts of damaged the tegument organs in the worms. Seventeen compounds in seed extract, on average, yielded a higher anthelmintic index on than praziquantel. Eleven of the 17 compounds exhibit stronger affinity than praziquantel, with routine and gallic acid being the top two ligands (∆Gbinding values: -11.65 kcal/mol and -11.07 kcal/mol, respectively). According to Lipinski's rule analysis, only routine compounds cannot be orally administered. The seeds of have potential as an anthelmintic agent for spp. at concentrations of 25%-40% (gr/v).