Human Escherichia coli O157:H7 genetic marker in isolates of bovine origin

The antiterminator Q gene of bacteriophage 933W (Q933) was identified upstream of the stx2 gene in 90% of human disease-origin Escherichia coli O157:H7 isolates and in 44.5% of bovine isolates. Shiga toxin production was higher in Q933-positive isolates than Q933-negative isolates. This genetic mark...

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Veröffentlicht in:	Emerging infectious diseases 2004-08, Vol.10 (8), p.1482-1485
Hauptverfasser:	Lejeune, Jeffrey T, Abedon, Stephen T, Takemura, Kaori, Christie, Nicholas P, Sreevatsan, Srinand
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cattle Cattle Diseases - microbiology Coliphages - genetics Dispatch E. coli O157 Escherichia coli Escherichia coli Infections - microbiology Escherichia coli O157 - classification Escherichia coli O157 - genetics Escherichia coli O157 - isolation & purification Escherichia coli O157 - virology Genetic Markers - genetics Humans Polymerase Chain Reaction Shiga Toxin 2 - genetics Shiga Toxin 2 - metabolism Shiga-toxin production stx2-encoding phages Viral Proteins - genetics
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Beschreibung
Zusammenfassung:	The antiterminator Q gene of bacteriophage 933W (Q933) was identified upstream of the stx2 gene in 90% of human disease-origin Escherichia coli O157:H7 isolates and in 44.5% of bovine isolates. Shiga toxin production was higher in Q933-positive isolates than Q933-negative isolates. This genetic marker may provide a useful molecular tool for epidemiologic studies.
ISSN:	1080-6040 1080-6059
DOI:	10.3201/eid1008.030784