Facial Hyperpigmentation: A Rare Side Effect of Adalimumab

Facial Hyperpigmentation: A Rare Side Effect of Adalimumab

This report describes a case of facial hyperpigmentation in a patient with Crohn's disease receiving adalimumab, a tumor necrosis factor (TNF)-alpha inhibitor. The onset of hyperpigmentation coincided with adalimumab administration, and its discontinuation resulted in significant improvement. H...

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Veröffentlicht in:JIM - high impact case reports 2024-01, Vol.12, p.23247096241265896
Hauptverfasser: Mrad, Malek, Tabka, Mariam, Souissi, Asmahane, Chelly, Ines, Mokni, Mourad
Format: Artikel
Sprache:eng
Schlagworte:
Adalimumab - adverse effects
Adult
Anti-Inflammatory Agents - adverse effects
Anti-Inflammatory Agents - therapeutic use
Crohn Disease - drug therapy
Face - pathology
Female
Humans
Hyperpigmentation - chemically induced
Hyperpigmentation - pathology
Male
Tumor Necrosis Factor-alpha - antagonists & inhibitors
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Zusammenfassung:This report describes a case of facial hyperpigmentation in a patient with Crohn's disease receiving adalimumab, a tumor necrosis factor (TNF)-alpha inhibitor. The onset of hyperpigmentation coincided with adalimumab administration, and its discontinuation resulted in significant improvement. Histopathological findings suggest a postinflammatory process at the dermo-epidermal junction. However, the precise mechanism remains unclear.
ISSN:2324-7096
2324-7096
DOI:10.1177/23247096241265896