Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression

Inhibition of Drp1 Sensitizes Cancer Cells to Cisplatin-Induced Apoptosis through Transcriptional Inhibition of c-FLIP Expression

Mitochondrial fragmentation occurs during the apoptosis. Dynamin-related protein 1 (Drp1) acts as an important component in mitochondrial fission machinery and can regulate various biological processes including apoptosis, cell cycle, and proliferation. The present study demonstrates that dysfunctio...

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Veröffentlicht in:Molecules (Basel, Switzerland) Switzerland), 2020-12, Vol.25 (24), p.5793
Hauptverfasser: Woo, Seon Min, Min, Kyoung-Jin, Kwon, Taeg Kyu
Format: Artikel
Sprache:eng
Schlagworte:
Antineoplastic Agents - pharmacology
Apoptosis
Apoptosis - drug effects
Apoptosis - genetics
Biological activity
c-FLIP
c-FLIP protein
Cancer therapies
CASP8 and FADD-Like Apoptosis Regulating Protein - genetics
Caspase-3
Caspases - metabolism
Cell cycle
Cell death
Cell Line, Tumor
Chemotherapy
Cisplatin
Cisplatin - pharmacology
Combined treatment
Drp1
Drug dosages
Drug resistance
Drug Resistance, Neoplasm - genetics
Dynamin
Ectopic expression
FLIP protein
Humans
Hypoxia
Kidney cancer
Kidney Neoplasms - genetics
Ligands
Low concentrations
Mdivi-1
Mitochondria
Morphology
Ovarian cancer
Oxidative stress
Phosphorylation
Population
Proteins
Quinazolinones - pharmacology
Renal cell carcinoma
Transcription
Transcription, Genetic - drug effects
Tumor cell lines
Tumor necrosis factor-TNF
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Zusammenfassung:Mitochondrial fragmentation occurs during the apoptosis. Dynamin-related protein 1 (Drp1) acts as an important component in mitochondrial fission machinery and can regulate various biological processes including apoptosis, cell cycle, and proliferation. The present study demonstrates that dysfunction of mitochondrial dynamics plays a pivotal role in cisplatin-induced apoptosis. Inhibiting the mitochondrial fission with the specific inhibitor (Mdivi-1) did not affect apoptotic cell death in low concentrations (
ISSN:1420-3049
1420-3049
DOI:10.3390/molecules25245793