Reducing motion sensitivity in 3D high-resolution T2-weighted MRI by navigator-based motion and nonlinear magnetic field correction

T2*-weighted gradient echo (GRE) MRI at high field is uniquely sensitive to the magnetic properties of tissue and allows the study of brain and vascular anatomy at high spatial resolution. However, it is also sensitive to B0 field changes induced by head motion and physiological processes such as the respiratory cycle. Conventional motion correction techniques do not take these field changes into account, and consequently do not fully recover image quality in T2*-weighted MRI. Here, a novel approach was developed to address this by monitoring the B0 field with a volumetric EPI phase navigator. The navigator was acquired at a shorter echo time than that of the (higher resolution) T2*-weighted GRE imaging data and accelerated with parallel imaging for high temporal resolution. At 4 ​mm isotropic spatial resolution and 0.54 ​s temporal resolution, the accuracy for estimation of rotation and translation was better than 0.2° and 0.1 ​mm, respectively. The 10% and 90% percentiles of B0 measurement error using the navigator were −1.8 and 1.5 Hz at 7 T, respectively. A fast retrospective reconstruction algorithm correcting for both motion and nonlinear B0 changes was also developed. The navigator and reconstruction algorithm were evaluated in correcting motion-corrupted high-resolution T2*-weighted GRE MRI on healthy human subjects at 7 ​T. Excellent image quality was demonstrated with the proposed correction method. •A time-resolved volumetric EPI phase navigator at a short echo time was developed with high accuracy for measuring head motion and nonlinear B0 field changes during a 3D T2*-weighed MRI scan.•A fast retrospective algorithm was developed to compensate motion and nonlinear B0 changes for 3D T2*-weighted GRE MRI.•Compared with motion and linear B0 correction, nonlinear B0 correction was shown to further reduce artifacts.